Screening for 392 polymorphisms in 141 pharmacogenes

Screening of LEP gene polymorphisms as a risk factor for obesity and type 2 diabetes in Iraqis

The prevalence of obesity and diabetes changes dramatically with lifestyle and unequal risk among individuals have made scientists interested to understand how the environment interferes with genetic factors to make it so-called genetic predisposition. This study aimed to explore wherethe most variable region is in leptin gene and analyse  microsatellite repeats with direct sequencing in Iraqis...

Dmd061937 392..399

Human cytochromes P450 (P450s) play a major role in the biotransformation of drugs. The generated metabolites are important for pharmaceutical, medical, and biotechnological applications and can be used for derivatization or toxicological studies. The availability of human drug metabolites is restricted and alternative ways of production are requested. For this, microbial P450s turned out to be...

Bez nazwy-392

Suggesting Valid Pharmacogenes by Mining Linked Data

A standard task in pharmacogenomics research is identifying genes that may be involved in drug response variability, i.e., pharmacogenes. Because genomic experiments tended to generate many false positives, computational approaches based on the use of background knowledge have been proposed. Until now, those have used only molecular networks or the biomedical literature. Here we propose a novel...

The role of contact endoscopy in screening for premalignant laryngeal lesions: a study of 141 patients.

At their earliest stage, pathologic lesions of the laryngeal epithelium are macroscopically invisible. Ideally, these lesions should be detected before their clinical manifestations appear so that prompt management can be initiated. However, most diagnostic modalities are unable to detect early premalignant lesions. We conducted a retrospective study of the use of contact endoscopy in analyzing...